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Li PQ, Ou S, Shi C, Shao

Longo and colleagues have synthesized a small molecule BDNF mimetic that activates the TrkB receptor and facilitates motor learning in traumatic brain injured rats [18]

Despite the encouraging results of GLP-1/glucagon co-agonism in experimental models, different GLP-1 and glucagon co-agonists have shown various levels of efficacy and tolerability in people with obesity and/or T2D, in early phase clinical trials, which may be explained by the different ratio of GLP-1 to glucagon activity between the different molecules [65]

Sep 2016;4(5):857-65

Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine