Daily administration of two or more synaptogenic compounds simultaneously might overwhelm cellular synthetic capacity or trigger compensatory downregulation faster than either compound would alone, potentially favoring alternating administration schedules where different compounds are used on different days
doi:10.1155/2012/324832 Pickart L, Margolina A
Environmental factors might cause the gene to be triggered
AFB1 can be transformed by microsomal cytochrome P450 enzyme, inducing cellular oxidative stress and forming highly reactive AFB1-exo 8,9-epoxide that can form adducts with DNA and other cellular macromolecules, thereby contributing to its carcinogenic, teratogenic and mutagenic activity (Eaton and Gallagher, 1994
Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: unraveling potential therapeutic avenues