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The duration of a B12 injections effects varies, but most people experience benefits for a few weeks to a few months

HYDROXO-B12 Injection contains hydroxocobalamin as the active ingredient which is a form of vitamin B12

First, they suggest that AOD-9604 can be used for extended periods without loss of efficacy due to antibody neutralization

In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)

Adding 1ml creates a concentration of 10mg/ml