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Nat Rev Mol Cell Biol 8(2):101112 Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995) The swedish mutation causes early-onset Alzheimers disease by -secretase cleavage within the secretory pathway

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Concurrent deficiencies in vitamin D, likely due to reduced sunlight exposure, and fluctuations in estradiol, progesterone, and DHEAS, especially among premenopausal women and extreme chronotypes, further exacerbate endocrine disruption 272

Financial support and sponsorship Supported in part by NIH grant R01 AG057381

Practical learning forms a key part of this course, allowing students to gain confidence in administering Vitamin B12 injections safely and effectively