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One such agent is Olorofim, a dihydroorotate dehydrogenase inhibitor currently in advanced clinical development, which impairs mitochondrial pyrimidine biosynthesis, leading to defective DNA synthesis and subsequent fungal cell death (Oliver et al., 2016)

A key component of our standard program is Intravenous Laser Blood Irradiation (ILBI)

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Moreover, in a transgenic mouse model with kidney-specific overexpression of CD36, increased triglyceride and long-chain FA accumulation was insufficient to induce renal fibrosis, further supporting the notion that reduced FAO activityrather than lipid storage aloneis more directly associated with fibrogenic progression in TECs (Kang et al., 2015)