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however, most clinical studies and meta-analyses have not controlled for various confounding factors, such as dose, duration, and type of PPI exposure, the inclusion and exclusion criteria were also insufficiently stringent across these studies

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Another miRNA shown to regulate Nrf2 is miR-34, able not only to target NFE2L2 but also downstream genes involved in cellular response to OS, such as microsomal glutathione S-transferase 1 ( Mgst1 ) and Sirtuin 1 ( Sirt1 ) genes in rat liver during aging [226]

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Preprint at bioRxiv (2022)