For example, vactosertib, an orally bioavailable TGF- receptor kinase inhibitor, showed efficacy against multiple myeloma in preclinical models, either as a monotherapy or in combination with other treatments [343, 344], leading to the clinical assessment of vactosertib
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Synergy, additive effects, and antagonism of drugs with plant bioactive compounds
In some embodiments, the otoprotectant is a compound of Formula (XI) having the structure of Formula (XIa): In some embodiments, the otoprotectant is any one of the following compounds: or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate or hydrate, pharmaceutically acceptable salt hydrate, or pharmaceutically acceptable prodrug thereof
