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Nevertheless, the contributory role of the TJ protein in mucosal barrier properties and pathobiology remains undeniable, but discerning their separate roles in barrier deregulation and epithelial morphogenesis appears to be a truly difficult task, at least given current technologies and model systems

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Disclosure of interest: All author have nothing to disclose

Androgen receptor (AR) and estrogen receptor (ER) signaling pathways undergo significant impairment, compromising testosterone biosynthesis and normal spermatogenesis

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