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Oxidative stress and blood-brain barrier dysfunction under particular consideration of matrix metalloproteinases

Glutathione IV Therapy is particularly effective when taken before alcohol consumption

To develop REPAIR, the Cas13b ortholog was mutated to be catalytically dead Cas13b (dCas13b) and fused with the adenosine deaminase acting on RNA 2 (ADAR2) enzymeallowing for the replacement of adenosine (A) residues to inosine (I) residues on mRNA transcripts

The study cohort included individuals with ALF (n=6), individuals who underwent surgical resection for angioma (n=27), and healthy individuals (HCs) (n=9)