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Where indicated (see Results, specifically concerning the association between the GST-Pi gradient and 12-month eGFR), this was by the method of Bonferroni, accounting for 41 comparisons (biomarkers specified in advance, accounting for where markers were measured at more than one timepoint, and the associated gradient)

Ladda MA, Goralski KB

[15] Optic neuritis, which is common in RR MS, has similarities with Lebers hereditary optic neuropathy (LHON), a known mitochondrial failure syndrome which also can feature demyelination

Anti-estrogen-based endocrine therapies, such as the ER modulator Tamoxifen, ER degrader Fulvestrant, and the aromatase inhibitor Letrozole, have significantly enhanced the survival rates of patients with hormone receptor-positive (HR+) breast cancer [5]

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