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Unexpectedly, we observed a biphasic effect: early sensitization to ferroptosis induced by glutathione depletion was subsequently counteracted by a marked increase in ferroptosis resistance

While their preclinical efficacy is promising, clinical translation has been limited by poor bioavailability

From a health economics perspective, lifelong B12 supplementation should involve cost-effective delivery routes and tailored dosages to optimise clinical outcomes while minimising excess

It all boils down to the need of the patient, even when the injectables are good but oral supplements are also acceptable depending on the needs of the patient

Glutathione transferases: a structural perspective