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Why Peter chose a paper on metformin, how metformin works, and why it generated excitement as a longevity-enhancing agent [9:00]

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Jaeschke, H., McGill, M

Deacetylation As the principal mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin3 regulates protein activity and stability through substrate-specific lysine deacetylation (Kac), thereby participating in pathophysiological processes such as cellular oxidative stress, autophagy, and cell death [36]

He may never die, he said