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Smoke-induced activation of defense related mechanisms was further supported by substantial induction of TLR-signaling associated Wfdc21 and Wfdc17 ( Marco , Clec4d , Mif , Lyz2 , Mmp12 ) ( Figures 3A, B )

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In our conditions, added to increased heart rate, acute and chronic exposure to nicotine increased the rate of contraction and relaxation of the calcium transient