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Abstract The human microbiome harbors a diverse array of microbes which establishes a mutually beneficial relation with the host in healthy conditions, however, the dynamic homeostasis is influenced by both host and environmental factors

Illegal tobacco is sold at pocket money prices, undercutting legitimate business and encouraging people, particularly children and young people, who might otherwise be deterred by cost to get hooked on smoking

Use Nicotine Replacement Therapy (NRT): NRT products, like nicotine patches or gum, can help manage withdrawal symptoms by providing a controlled dose of nicotine without the harmful chemicals found in tobacco products

Tobacco prices remained low until the 1730s, and stable through the 1740s and 1750s