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CCN1 , also known as Cyr61 , was found to be upregulated in lung epithelial cells by CSE via the induction of ROS and endoplasmic reticulum stress, which subsequently resulted in augmented IL - 8 release through the activation of the Wnt pathway [193]

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The anodization process creates a hard, corrosion-resistant surface that prevents flaking and maintains structural integrity through extended use

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