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Glutaminase converts glutamine (predominantly derived from the liver but also from many other tissues) to glutamate and NH 4 + , with the NH 4 + being excreted in the urine

This would allow it to stay in the bloodstream longer for increased nitric oxide uptake into the muscles, which would in turn lead to an increase in strength and lean body mass via more efficient muscle protein synthesis

This effect was not sensitive to naloxone, indicating a distinct mechanism from its opioid-mediated antinociceptive effects 8