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Combination treatment with TQ and cisplatin showed hindrance in tumorigenesis evident from diminished expression of proliferation markers, a concomitant enhancement of double strand DNA break and apoptotic cell death were also observed (Jafri et al., 2010

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Only six new fragments showed a peak reduction of greater than 20% in the CPMG assay (Supplementary Table 2), a similar degree of hit validation to the first XChem screen