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Anything that depletes antioxidants, or increases numbers of destructive oxidants, resulted in oxidative stress ( 1 )

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This strategy shows great promise in treating complicated disorders like carcinoma, where the synergistic impact of multiple drugs may boost treatment outcomes and overcome drug resistance

Single-nucleotide polymorphisms (SNPs) in organic cation transporters (OCT1/SLC22A1, OCT2/SLC22A2, OCT3/SLC22A3) significantly impact drug pharmacokinetics through altered intestinal absorption, hepatic distribution, and renal clearance (105)