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In the fifties, when chemo wasnt yet widely used, high-dose B12 shots (10,000g) were given to children with a neuroblastoma tumor, every two days, for 2-3 years

Without offering a citation for a published paper or sharing any data, Sikirics 2025 review states that this clinical trial found that the drug was safe and well-tolerated in humans

By inhibiting NNMT, the compound preserves these critical cofactors, restoring sirtuin activity and normal energy expenditure in adipocytes

Not approved for human consumption or veterinary use

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