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The FDA Commissioner released a statement regarding new enforcement actions and a plan to prevent youth e-cigarette use, specifically calling out JUUL, in August, 2018 and an additional statement in November 2018 with plans to limit access to flavored tobacco products

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In the lungs, there was a significant increase in IL-33 and IL-13, which caused mast cell degranulation and histamine release

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Availability of data and materials The dataset used and analysed during the current study are available from the corresponding author on reasonable request