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Targeting mitochondria to restore exhausted T cell antitumor function By targeting T cell mitochondria metabolism, enhancing mitochondrial biogenesis, and improving mitochondrial structure and function to restore the energy supply and function of exhausted T cells, the strategies that have been applied up to date are as follows (Table 1)
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As the integrity of subcellular membranes depends heavily on GP, which in turn depends on selenium, the mechanism of GP is at the Selenocystein site, in a Se - form at resting state