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Therapeutically, p53 activation dualistically regulates apoptosis and ferroptosis to suppress PCa growth, but ferroptosis-driven macrophage polarization in the TME may inadvertently promote tumor metastasis [Figure 2A], emphasizing the need for context-specific modulation to balance efficacy and paradoxical outcomes

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The NHS schedule for treating B12 deficiency is a loading dose of 1mg hydroxocobalamin by intramuscular injection every two to three days for two weeks, then a maintenance dose every two to three months for life when the cause is non-dietary