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Activation of immune system in colonic mucosa followed by infiltration of numerous immune cells and release of inflammatory cytokines are observed in IBS patients as compared to healthy subjects (Martin-Vias and Quigley, 2016

Petucci, C

This inflammation further damages the gut lining, worsening the leaky gut and ensuring that even more foods become triggers over time

The mechanisms of development of metal-induced hepatic steatosis were shown to involve oxidative stress, endoplasmic reticulum (ER) stress, pyroptosis, and induction of an inflammatory response[11,12]