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Acute insulin application in the ventral tegmental area in vitro diminishes somatodendritic dopamine levels via increased dopamine transporter activity, mediated by PI3K and mammalian target of rapamycin (mTOR) signaling pathways [90]

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More impressively, in chronic unpredictable stress models, BPC-157 maintained effectiveness at 4-day and 6-day timepoints while imipramine required prolonged treatment

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