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The collaborative innovation of natural and synthetic peptides will provide a therapeutic paradigm with both efficacy and safety in this field

To confirm the barrier tightness of the BBB model, Transendothelial Electrical Resistance (TEER) measure readings were performed using a chopstick electrode STX2 coupled to EVOM Volt/Ohm meter (World Precision Instruments, Sarasota, Florida, USA)

All authors critically revised the manuscript and provided full approval of version to be published

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Preliminary data suggests that retatrutide could lead to more weight loss than semaglutide or tirzepatide because it targets more receptors involved in suppressing appetite and lowering blood sugar