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It is tempting to speculate that an attenuated anti-oxidant response with elevated ROS in COPD [21, 22, 28, 36] may lead to an increased oxidant burden, possibly contributing to the observed mitochondrial defects in bronchial epithelial cells from COPD patients [6, 32, 37]

Data arising from the Iowa Womens Health Study, further supports a link between smoking levels and OR for CP

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