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No data suggests that very high supplementation levels are any more effective at boosting a persons immune system or bodily functions if they do not have a vitamin B12 deficiency

Ibdah JA, Perlegas P, Zhao Y, Angdisen J, Borgerink H, Shadoan MK, Wagner JD, Matern D, Rinaldo P, Cline JM (2005) Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance

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A randomized phase III clinical trial involving 600 early PD patients found no evidence of clinical benefit with high-dose CoQ 10 (1200 mg/d and 2400 mg/d) supplementation (207)