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Nasal DPI Peptides for CNS Therapy/Disease Application The IN delivery of proteins and peptides to the CNS allows for the treatment of neurodegenerative diseases such as AD [103], PD [104,105,106], and multiple sclerosis [107,108], among others

Smoking also increases risk by reducing blood flow to spinal structures and impairing tissue repair

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Not specific to IGF-1 LR3 but pathway-relevant

The life cycle of skin melanocytes consists of several steps, including lineage specification from embryonic neural crest cells (melanoblasts), migration and proliferation of melanoblasts, differentiation of melanoblasts into melanocytes with dendritic morphology 23