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Looking for the next step in the treatment for T2D and overweight/obesity, combinations of GLP-1 with other entero-pancreatic hormones with diverse metabolic actions, such as glucose-dependent insulinotropic peptide (GIP), glucagon, and amylin (Figure 1) are currently under development with the potential of achieving euglycemia together with 10% and even 15% WL for many people living with T2D

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J Med Chem 61:75037524 Amberg W, Pohlki F, Lange U, Li H-Q, Brewer JT, Zanze I, Dietrich J, Vasudevan A, Djuric SW, Lao Y (2017) Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy