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Adequate Vitamin B12 levels contribute to better overall health, reduced risk of anemia, improved nerve health, and enhanced energy levels

Addressing mitochondrial dysfunction, redox imbalance, and impaired energy metabolism could lead to more effective treatments

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Finally, heterogeneity in ascent profiles, altitude reached, duration of exposure, and supplementation protocols, quantified by the I 2 statistic and addressed using a random-effects model, may have contributed to variability across studies and constrained further stratified or sensitivity analyses

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