41,42 Although humans can excrete small amounts of mercury in urine or feces as well as via exhalation or sweating, they lack an active robust mechanism for mercury excretion, allowing levels to accumulate with chronic exposure
At secondary sites such as the lung, fibroblasts upregulate fibronectin, which serves as a docking site for hematopoietic progenitor cells and the subsequent arrival of tumor cells
Laboratory investigations show restored kidney function in both fast aging and naturally aged mouse models, suggesting senescent cell elimination can reverse organ-specific age-related decline
Lifestyle changes and dietary guidance are also integral to the process
In vitro experiments have shown that paeoniflorin can upregulate the expression levels of SLC7A11, thereby inhibiting ferroptosis in renal tubular epithelial cells, providing a potential therapeutic strategy for protecting kidney tissues (182)