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The therapeutic window appears well-established at these dosing levels, with higher doses unlikely to provide proportional additional benefits while potentially increasing adverse events

Hillerer KM, Slattery DA, Pletzer B

Overall Safety and Tolerability Assessment The primary safety conclusion from the comprehensive trial program was unambiguous: AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo

He had a meniscus tear in one knee that didnt require surgery and then injured his other knee

Because TB-500 reaches all tissues rather than concentrating at one site, the dosing strategy focuses on sustaining a systemic therapeutic level across the cycle rather than targeting a precise anatomical location