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Int J Mol Sci 26:5488

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Structural and functional aspects of filamins

The vitrification process leads to mitochondrial dysfunction, characterized by a reduction in mitochondrial membrane potential (MMP), an increase in ROS, and elevated mitochondrial Ca 2+ levels ( Mechanistically, oxidative stress compromises mitochondrial integrity primarily through the activation of the ASK1JNKBcl-2/Bax apoptotic axis