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Patients have been "tanked up" with daily injections, followed by weekly and then periodic ones that may continue the rest of their lives
Additionally, if OCSCs are exposed to inflammatory mediators, undergo mesenchymal endothelial transformation, or experience dysregulation of the redox balance in the tumor microenvironment (TME), they may stimulate the continuous proliferation of OCSCs, potentially leading to OC development (63)
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Finally, B1 cells need to migrate to niches that support antibody production in order to increase secretion of IgM OSE
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