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Furthermore, the relative abundance of Akkermansia , a genus positively associated with improvements in obesity-related metabolic issues 60 , was increased in the vehicle-treated group that underwent diet switch relative to the WD control group, suggesting a potential for distinct microbiome-mediated mechanisms of weight loss subsequent to diet switch from those of diet switch in combination with 5A-1MQ treatment

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2019. MOTS-c regulates adipose homeostasis and prevents metabolic dysfunction

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It does not increase adrenaline, cortisol, or any other wake-promoting neurotransmitter through its primary mechanism of action