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showed that ARF inhibits the ability of NRF2 to transcriptionally activate its target gene SLC7A11 in vivo and in vitro and regulates the ferroptosis response in a p53-dependent and p53-independent manner

Therefore, if taurolidine/heparin does not receive FDA approval by July 1, 2023 to receive new technology add-on payments beginning with FY 2023, per 412.87(e)(3), we are proposing to conditionally approve taurolidine/heparin for new technology add-on payments for FY 2024, subject to the technology receiving FDA marketing authorization by July 1, 2024