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High Oxygen Consumption: The brain, despite accounting for only about 2% of body weight, consumes approximately 20% of the body's oxygen

Imaging 20 : 4557 (2001)

These modifications in metabolism pathways resulted in a substantial increase in the levels of 39 metabolites in acute COVID 19 patients compared to the R group such as phenylaniline, pyrimidodiazepine, xanthine, ascorbate, kynurenine, 5-hydroxykynurenine and others as outlined in Supplementary Figures 8A, B

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This forms a vicious cycle of iron overload inflammation BBB damage increased iron permeability, further aggravating disease progression