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5-Amino-1MQ inhibits the NNMT enzyme to theoretically raise NAD+ levels and improve insulin sensitivity, but evidence is limited to preclinical animal studies only

PMID: 42198468 Pharmaceuticals (Basel) Refined Jianpi Huayu Jiedu Decoction Attenuates TAM-Induced Spasmolytic Polypeptide-Expressing Metaplasia (SPEM) by Modulating LCN2-Associated Mitochondrial Dysfunction

This suggests that NCOA4 in AD may be translocated to the cytoplasm, where it could induce the degradation of ferritin and increase sensitivity to ferroptosis [41]

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