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In summary, the aforementioned nanodrug delivery systems, by achieving specific responses to MMP-rich microenvironmental stimuli, controlled drug release and multiple mechanisms of action (such as enhancing the permeability and retention effect, triggering immune responses, synergizing with radiotherapy, inhibiting invasion and crossing the BBB), provide powerful novel strategies for precisely targeting and modulating MMP-related key pathological processes in GBM (Table SIV)

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