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Neuroplasticity driven by HGF/c-Met signaling includes upregulation of brain-derived neurotrophic factor (BDNF), activation of postsynaptic density protein-95 (PSD-95), and increased expression of GluN2B-containing NMDA receptors

They may also be necessary when certain medications interfere with B12 absorption or in any other diagnosed condition specifically impacting B12 uptake

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Consistently, increased shrunken mitochondria and lipid ROS were observed in VRK2 knockdown cells in the presence of TBHP (Fig