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For a pack-a-day smoker spending $10 per pack, the yearly cost is $3,650

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The letter pointed to Massachusetts and California, both of which have enacted flavored tobacco sales bans, as examples of states that saw an expansion of the illicit tobacco market after flavors were prohibited

Campaigns by tobacco companies warning about the health hazards of smoking tobacco of dubious origin fall on deaf ears, as more and more smokers resort to them

In vitro studies have compared the relative toxicity of flavoring chemicals and identified both flavor-dependent and flavor-independent [i.e., nicotine, propylene glycol (PG), and glycerin (GLY)] effects on indices of cytotoxicity (42) and inflammatory response (43)