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Dose-dependent increase in oxidative stress in Leydig cells leading to cytotoxicity, cell death, and impaired gonadal function

Sleep disruption when injected later in the day

When research on a particular compound comes almost exclusively from one geographic region and institutional network, there is inherent risk of confirmation bias, methodological preferences that favor positive findings, and results that may not generalize to other populations or research contexts

Given that fact that a significant percentage of the general population does not consume adequate dietary levels for several micronutrients (145), a daily multivitamin/mineral supplement could help improve micronutrient status and possibly have some cognitive and other health benefits

doi: 10.1124/pr.116.013227