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INH is mainly metabolized in the liver through two major pathways to metabolites such as acetyl isoniazid (AcINH), hydrazine (Hz), acetyl hydrazine (AcHz), diacetyl hydrazine (DiAcHz), and isonicotinic acid (INA), primarily mediated by arylamine N-acetyl transferase2 (NAT2) and amidases (Wang et al., 2016