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In the late 19th and early 20th centuries, researchers made important discoveries about the neuropathology of Parkinson's disease, including the loss of dopaminergic neurons in the substantia nigra region of the brain

Although tamoxifen and its metabolites (i.e., 4-hydroxytamoxifen) can cross the blood-brain barrier, these compounds have reduced bioavailability in the brain compared to other tissues 34

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Li Z, Alam S, Wang J, Sandstrom CS, Janciauskiene S, Mahadeva R

Besides lightening dark areas, kojic acid also has antioxidant properties that protect skin from damage caused by UV rays and pollution