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doi: 10.1016/j.bbi.2021.01.003 138 PallastSAraiKWangXLoEHvan LeyenK

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In low doses, caffeic acid, when combined with caffeine, exhibits anxiolytic, antidepressant, and anti-inflammatory effects by reducing LPS-induced depressive-like behavior and decreasing TNF-alpha and IL-6 levels [34]