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Our findings on clinical outcome were consistent with studies assessing in vivo biomarkers of e-cigarette exposure in animal subjects, human participants, and population studies, the authors wrote

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A little-known tobacco technology, Heat-not-Burn (HNB), has the potential to slash smoking-related death and disease by appealing to the millions of smokers who've failed to quit using e-cigarettes and traditional nicotine-replacement therapies

[92] Corticotropin-releasing factor, Neuropeptide Y, orexins, and norepinephrine are involved in nicotine addiction

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