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5.2 Safety and toxicological concerns Even as nanoencapsulation solves bioavailability issues, it introduces new questions about the safety of ingesting nanoparticles over time

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Neuropsychiatric disorders: predominance of astrocytic atrophy and loss of function Mood disorders Major depressive disorder (MDD) Decreases in the total number of glial cells and astrocytes are the main and most consistent histopathological hallmark of MDD post-mortem brains