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Mechanistically, GSH depletion does not cause global protein oxidation but instead selectively oxidizes and destabilizes fatty acid synthase while decreasing lipogenic gene expression at the transcriptional level, collectively suppressing lipogenesis

Journal of Pharmaceutical Sciences .

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"The natural antioxidant defenses in our body decline as we age, which leads to increased oxidative stress that causes melanocytes to be impaired and produce less melanin, contributing to the loss of hair pigment," Wizemann explains."A lack of antioxidant-rich foods, regular exercise and sleep as well as smoking, excessive stress and alcohol consumption all increase oxidative stress." Deficiencies in vitamins and minerals

Insulin secretion increases, but only when blood sugar is elevated