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As it has been shown previously in this cohort that drinking 15-21 units per week and over leads to an increased risk of mortality[20], the cut-off of 15 was a reasonable choice, although we do not have sufficient data on consumption throughout the follow-up period to recommend changing the weekly limits

Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis

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