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Patients with chronic kidney disease or renal tubular dysfunction have reduced capacity to regulate acid base balance and are therefore particularly vulnerable to metabolic alkalosis, electrolyte disturbances, and mineral accumulation

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This reduction in circulating histamine may help mitigate the inappropriate vasodilation that drives severe blood pooling and orthostatic intolerance

Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin

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